In general, though I haven't listened to a lot of podcast shows, I think I've inadvertantly listened to some of the best around. I started with Nightvale, which is creepy and funny and wonderful. Alice Isn't Dead was good (and you have to love the logo for it), and our daughter recommended Serial and S-Town, both of which were terrific. But I'm having trouble finding other shows that seem appealing.
When I look for humor, I tend to find podcasts about 1) Dudes drinking beer and yakking, 2) Dudes getting stoned and yakking, and 3) Angry dudes. Ugh. Nightvale is humorous, but it's probably considered a drama series. The various other genres of people talking about art, TV, culture, theater, movies, books, politics, sports... meh. Actually, politics would be more likely to amp up my blood pressure, but who needs that?
So, what have YOU listened to that you really like? Do you have any podcasts to recommend?